Domain-domain interactions underlying herpesvirus-human protein-protein interaction networks.

ABSTRACT: Protein-domains play an important role in mediating protein-protein interactions. Furthermore, the same domain-pairs mediate different interactions in different contexts and in various organisms, and therefore domain-pairs are considered as the building blocks of interactome networks. Here we extend these principles to the host-virus interface and find the domain-pairs that potentially mediate human-herpesvirus interactions. Notably, we find that the same domain-pairs used by other organisms for mediating their interactions underlie statistically significant fractions of human-virus protein inter-interaction networks. Our analysis shows that viral domains tend to interact with human domains that are hubs in the human domain-domain interaction network. This may enable the virus to easily in

SUBMITTER: Itzhaki Z 

PROVIDER: S-EPMC3131297 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature