Nardosinane-type sesquiterpenoids from the formosan soft coral Paralemnalia thyrsoides.

ABSTRACT: Five new nardosinane-type sesquiterpenoids, paralemnolins Q-U (1-5), along with three known compounds (6-8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher's method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity.

SUBMITTER: Huang CY 

PROVIDER: S-EPMC3225934 | biostudies-literature |

REPOSITORIES: biostudies-literature