Transcriptomic analysis of human retinal detachment reveals both inflammatory response and photoreceptor death.

ABSTRACT:

Background

Retinal detachment often leads to a severe and permanent loss of vision and its therapeutic management remains to this day exclusively surgical. We have used surgical specimens to perform a differential analysis of the transcriptome of human retinal tissues following detachment in order to identify new potential pharmacological targets that could be used in combination with surgery to further improve final outcome.

Methodology/principal findings

Statistical analysis reveals major involvement of the immune response in the disease. Interestingly, using a novel approach relying on coordinated expression, the interindividual variation was monitored to unravel a second crucial aspect of the pathological process: the death of photoreceptor cells. Within the genes identi

SUBMITTER: Delyfer MN 

PROVIDER: S-EPMC3235162 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature