Dataset Information

Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

ABSTRACT:

Objective

To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA).

Methods

We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform activity using spike percentage, the percentage of 1-second bins in the EEG tracing containing at least 1 spike. PSPEA was present when spike percentage during non-REM sleep was ≥50% than spike percentage during wakefulness.

Results

One hundred patients with PSPEA (cases) and 47 patients without PSPEA (controls) met the inclusion criteria during a 14-year period. Both groups were comparable in terms of clinical and epidemiologic features. Early developmental lesions were more frequent in cases (48% vs 19.2%, p = 0.002). Thalamic lesions were more frequent in cases (14% vs 2.1%, p = 0.037). The main types of early developmental lesions found in cases were vascular lesions (14%), periventricular leukomalacia (9%), and malformation of cortical development (5%). Vascular lesions were the only type of early developmental lesions that were more frequent in cases (14% vs 0%, p = 0.005).

Conclusions

Patients with PSPEA have a higher frequency of early developmental lesions and thalamic lesions than a comparable population of patients without PSPEA. Vascular lesions were the type of early developmental lesions most related to PSPEA.

SUBMITTER: Sanchez Fernandez I

PROVIDER: S-EPMC3359583 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Publications

Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

Sánchez Fernández I I Takeoka M M Tas E E Peters J M JM Prabhu S P SP Stannard K M KM Gregas M M Eksioglu Y Y Rotenberg A A Riviello J J JJ Kothare S V SV Loddenkemper T T

Neurology 20120425 22

<h4>Objective</h4>To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA).<h4>Methods</h4>We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform a ...[more]

PMID: 22539569

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Dataset Information

Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

Objective

Methods

Results

Conclusions

Publications

Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

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