Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

ABSTRACT:

Objective

To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA).

Methods

We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform activity using spike percentage, the percentage of 1-second bins in the EEG tracing containing at least 1 spike. PSPEA was present when spike percentage during non-REM sleep was ≥50% than spike percentage during wakefulness.

Results

One hundred patients with PSPEA (cases) and 47 patients witho

SUBMITTER: Sanchez Fernandez I 

PROVIDER: S-EPMC3359583 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature