The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity.

ABSTRACT: This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in μg. Immunosuppression during spaceflight is a major barrier to safe, long-term human space habitation and travel. The goals of these experiments were to prove that μg was the cause of impaired T cell activation during spaceflight, as well as understand the mechanisms controlling early T cell activation. T cells from four human donors were stimulated with Con A and anti-CD28 on board the ISS. An on-board centrifuge was used to generate a 1g simultaneous control to isolate the effects of μg from other variables of spaceflight. Microarray expression analysis after 1.5 h of activation demonstrated that μg- and 1g-activated T cells had distinct patterns of global gene expression and

SUBMITTER: Chang TT 

PROVIDER: S-EPMC3501893 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature