Intensive blood-pressure control in hypertensive chronic kidney disease.

ABSTRACT:

Background

In observational studies, the relationship between blood pressure and end-stage renal disease (ESRD) is direct and progressive. The burden of hypertension-related chronic kidney disease and ESRD is especially high among black patients. Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients.

Methods

We randomly assigned 1094 black patients with hypertensive chronic kidney disease to receive either intensive or standard blood-pressure control. After completing the trial phase, patients were invited to enroll in a cohort phase in which the blood-pressure target was less than 130/80 mm Hg. The primary clinical outcome in the cohort phase was the progression of chronic kidney disease, w

SUBMITTER: Appel LJ 

PROVIDER: S-EPMC3662974 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature