Prenatal alcohol exposure and childhood atopic disease: a Mendelian randomization approach.

ABSTRACT:

Background

Alcohol consumption in western pregnant women is not uncommon and could be a risk factor for childhood atopic disease. However, reported alcohol intake may be unreliable, and associations are likely to be confounded.

Objective

We aimed to study the relation between prenatal alcohol exposure and atopic phenotypes in a large population-based birth cohort with the use of a Mendelian randomization approach to minimize bias and confounding.

Methods

In white mothers and children in the Avon Longitudinal Study of Parents and Children (ALSPAC) we first analyzed associations between reported maternal alcohol consumption during pregnancy and atopic outcomes in the offspring measured at 7 years of age (asthma, wheezing, hay fever, eczema, atopy, and total IgE). We the

SUBMITTER: Shaheen SO 

PROVIDER: S-EPMC3884122 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature