High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain.

ABSTRACT: The increasing use of mouse models for human brain disease studies presents an emerging need for a new functional imaging modality. Using optical excitation and acoustic detection, we developed a functional connectivity photoacoustic tomography system, which allows noninvasive imaging of resting-state functional connectivity in the mouse brain, with a large field of view and a high spatial resolution. Bilateral correlations were observed in eight functional regions, including the olfactory bulb, limbic, parietal, somatosensory, retrosplenial, visual, motor, and temporal regions, as well as in several subregions. The borders and locations of these regions agreed well with the Paxinos mouse brain atlas. By subjecting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak

SUBMITTER: Nasiriavanaki M 

PROVIDER: S-EPMC3890828 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature