Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae.

ABSTRACT:

Background

Specific histone modifications play important roles in chromatin functions; i.e., activation or repression of gene transcription. This participation must occur as a dynamic process. Nevertheless, most of the histone modification maps reported to date provide only static pictures that link certain modifications with active or silenced states. This study, however, focuses on the global histone modification variation that occurs in response to the transcriptional reprogramming produced by a physiological perturbation in yeast.

Results

We did a genome-wide chromatin immunoprecipitation analysis for eight specific histone modifications before and after saline stress. The most striking change was rapid acetylation loss in lysines 9 and 14 of H3 and in lysine 8 of H4, as

SUBMITTER: Magraner-Pardo L 

PROVIDER: S-EPMC3986647 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature