Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer.

ABSTRACT:

Background

The response of ovarian cancer patients to carboplatin and paclitaxel is variable, necessitating identification of biomarkers that can reliably predict drug sensitivity and resistance. In this study, we sought to identify dynamically controlled genes and pathways associated with drug response and its time dependence.

Methods

Gene expression was assessed for 14 days post-treatment with carboplatin or carboplatin-paclitaxel in xenografts from two ovarian cancer models: platinum-sensitive serous adenocarcinoma-derived OV1002 and a mixed clear cell/endometrioid carcinoma-derived HOX424 with reduced sensitivity to platinum.

Results

Tumour volume reduction was observed in both xenografts, but more dominantly in OV1002. Upregulated genes in OV1002 were involved in

SUBMITTER: Koussounadis A 

PROVIDER: S-EPMC4056064 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature