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Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine.


ABSTRACT:

SUBMITTER: Stucky NL 

PROVIDER: S-EPMC4079043 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine.

Stucky Nicholas L NL   Gregory Eugene E   Winter Michelle K MK   He Yong-Yue YY   Hamilton Eric S ES   McCarson Kenneth E KE   Berman Nancy E J NE  

Headache 20110501 5


<h4>Objective</h4>The objectives of this study were to develop a preclinical rodent model that produces migraine-like behaviors based on International Headache Society diagnostic criteria, to determine whether sex differences are present, and to determine whether expression of calcitonin gene-related peptide (CGRP) and the genes encoding its receptor in trigeminal ganglion or medulla correlates with those behaviors.<h4>Background</h4>Few animal studies of migraine have tested behaviors associate  ...[more]

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