Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains.

ABSTRACT: Natural variation in gene expression is pervasive within and between species, and it likely explains a significant fraction of phenotypic variation between individuals. Phenotypic variation in acute systemic responses can also be leveraged to reveal physiological differences in how individuals perceive and respond to environmental perturbations. We previously found extensive variation in the transcriptomic response to acute ethanol exposure in two wild isolates and a common laboratory strain of Saccharomyces cerevisiae. Many expression differences persisted across several modules of coregulated genes, implicating trans-acting systemic differences in ethanol sensing and/or response. Here, we conducted expression QTL mapping of the ethanol response in two strain crosses to identify the genet

SUBMITTER: Lewis JA 

PROVIDER: S-EPMC4174948 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature