Whole blood gene expression and interleukin-6 levels.

ABSTRACT:

Background

Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortality. The characterization of gene expression profiles associated with interleukin-6 levels might suggest important molecular events underlying its regulation.

Methods and results

We studied the association of transcriptional profiles with interleukin-6 levels in 2422 participants from the Framingham Heart Study Offspring Cohort using Affymetrix Human Exon 1.0 ST Array. We identified 4139 genes that were significantly associated with interleukin-6 levels (FDR<0.05) after adjusting for age, sex and blood cell components. We then replicated 807 genes in the InCHIANTI study with 694 participants. Many of the top genes are involved in inflammation-related p

SUBMITTER: Lin H 

PROVIDER: S-EPMC4262595 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature