Whole blood gene expression and interleukin-6 levels.
Ontology highlight
ABSTRACT: Background
Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortality. The characterization of gene expression profiles associated with interleukin-6 levels might suggest important molecular events underlying its regulation.Methods and results
We studied the association of transcriptional profiles with interleukin-6 levels in 2422 participants from the Framingham Heart Study Offspring Cohort using Affymetrix Human Exon 1.0 ST Array. We identified 4139 genes that were significantly associated with interleukin-6 levels (FDR<0.05) after adjusting for age, sex and blood cell components. We then replicated 807 genes in the InCHIANTI study with 694 participants. Many of the top genes are involved in inflammation-related pathways or erythrocyte function, including JAK/Stat signaling pathway and interleukin-10 signaling pathway.Conclusion
We identified and replicated 807 genes that were associated with circulating interleukin-6 levels. Future characterization of interleukin-6 regulation networks may facilitate the identification of additional potential targets for treating inflammation-related diseases.
SUBMITTER: Lin H
PROVIDER: S-EPMC4262595 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Whole blood gene expression and interleukin-6 levels.
Lin Honghuang H Joehanes Roby R Pilling Luke C LC Dupuis Josée J Lunetta Kathryn L KL Ying Sai-Xia SX Benjamin Emelia J EJ Hernandez Dena D Singleton Andrew A Melzer David D Munson Peter J PJ Levy Daniel D Ferrucci Luigi L Murabito Joanne M JM
Genomics 20141013 6 Pt B
<h4>Background</h4>Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortality. The characterization of gene expression profiles associated with interleukin-6 levels might suggest important molecular events underlying its regulation.<h4>Methods and results</h4>We studied the association of transcriptional profiles with interleukin-6 levels in 2422 participants from the Framingham Heart Study Offspring Cohort using Affymetrix Human Exon 1. ...[more]
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