Benign breast tissue composition in breast cancer patients: association with risk factors, clinical variables, and gene expression.

ABSTRACT:

Background

Breast tissue composition (epithelium, non-fatty stroma, and adipose) changes qualitatively and quantitatively throughout the lifespan, and may mediate relationships between risk factors and breast cancer initiation. We sought to identify relationships between tissue composition, risk factors, tumor characteristics, and gene expression.

Methods

Participants were 146 patients from the Polish Breast Cancer Study, with data on risk factor and clinicopathological characteristics. Benign breast tissue composition was evaluated using digital image analysis of histologic sections. Whole-genome microarrays were performed on the same tissue blocks.

Results

Mean epithelial, non-fatty stromal, and adipose proportions were 8.4% (SD = 4.9%), 27.7% (SD = 24.0%), and 64.0

SUBMITTER: Sun X 

PROVIDER: S-EPMC4278568 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature