IIIDB: a database for isoform-isoform interactions and isoform network modules.

ABSTRACT:

Background

Protein-protein interactions (PPIs) are key to understanding diverse cellular processes and disease mechanisms. However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that "proteins" of currently known PPIs generally refer to "genes." It is known that alternative splicing often impacts PPI by either directly affecting protein interacting domains, or by indirectly impacting other domains, which, in turn, impacts the PPI binding. Thus, proteins translated from different isoforms of the same gene can have different interaction partners.

Results

Due to the limitations of current experimental capacities, little data is available for PPIs at the resolution of isoforms, although such high-resolution data is crucial to map pathways and

SUBMITTER: Tseng YT 

PROVIDER: S-EPMC4331710 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature