Systemic lupus erythematous and malignancy risk: a meta-analysis.

ABSTRACT:

Background

Pilot studies have estimated cancer incidence in patients with systemic lupus erythematous (SLE). However, the results have been inconclusive. To ascertain the correlation between SLE and malignancy more comprehensively and precisely, we conducted a meta-analysis.

Methods

PubMed, the Cochrane Library and Embase databases through June 2014, were searched to identify observational studies evaluating the association between SLE and malignancy. The outcomes from these studies were measured as relative risks (RRs). A random or fixed effects model was chosen to calculate the pooled RR according to heterogeneity test. Between-study heterogeneity was assessed by estimating I2 index. Publication bias was assessed by Egger's test.

Results

A total of 16 papers, includ

SUBMITTER: Cao L 

PROVIDER: S-EPMC4401738 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature