Association between four MMP-9 polymorphisms and breast cancer risk: a meta-analysis.

ABSTRACT:

Background

The role of matrix metalloproteinase 9 (MMP-9) polymorphisms in breast cancer risk remains unclear. The purpose of this study was to evaluate the association between MMP-9 variants and breast cancer susceptibility.

Material and methods

Case-control studies were searched on electronic databases to retrieve related articles published between 2000 and 2014 concerning the role of MMP-9 variants in breast cancer risk. Pooled odds ratios (OR) with correlative 95% confidence intervals (CI) were employed to assess this association.

Results

Ten articles were screened out, including 6177 breast cancer patients and 6726 matched-controls. For rs3918242 (-1562 C/T), 6 studies contained 1435 patients and 1446 controls. Although the frequency of risk allele C was higher i

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4413812 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature