Childhood maltreatment, altered limbic neurobiology, and substance use relapse severity via trauma-specific reductions in limbic gray matter volume.

ABSTRACT:

Importance

Substance use disorders (SUDs) are among the most common sequelae of childhood maltreatment, yet the independent contributions of SUDs and childhood maltreatment to neurobiological changes and the effect of the latter on relapse risk (a critical variable in addiction treatment) are relatively unknown.

Objectives

To identify structural neural characteristics independently associated with childhood maltreatment (CM; a common type of childhood adversity), comparing a sample with SUD with a demographically comparable control sample, and to examine the relationship between CM-related structural brain changes and subsequent relapse.

Design, setting, and participants

Structural magnetic resonance imaging study comparing 79 treatment-engaged participants with SUD i

SUBMITTER: Van Dam NT 

PROVIDER: S-EPMC4437819 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature