Comparison of optical coherence tomography assessments in the comparison of age-related macular degeneration treatments trials.

ABSTRACT:

Objective

To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD).

Design

Cross-sectional study within the Comparison of AMD Treatments Trials (CATT).

Participants

During year 2 of CATT, 1213 pairs of SD OCT and TD OCT scans were compared from a subset of 384 eyes.

Methods

Masked readers independently graded OCT scans for presence of intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid and performed manual measurements of retinal, SRF, and subretinal tissue complex thicknesses at the foveal center.

Main outcome measures

Presence of fluid was evaluated

SUBMITTER: Folgar FA 

PROVIDER: S-EPMC4515372 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature