Ontology highlight
ABSTRACT:
SUBMITTER: Ambasudhan R
PROVIDER: S-EPMC4567246 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Ambasudhan Rajesh R Talantova Maria M Coleman Ronald R Yuan Xu X Zhu Saiyong S Lipton Stuart A SA Ding Sheng S
Cell stem cell 20110728 2
Human induced pluripotent stem cells (hiPSCs) have been generated by reprogramming a number of different somatic cell types using a variety of approaches. In addition, direct reprogramming of mature cells from one lineage to another has emerged recently as an alternative strategy for generating cell types of interest. Here we show that a combination of a microRNA (miR-124) and two transcription factors (MYT1L and BRN2) is sufficient to directly reprogram postnatal and adult human primary dermal ...[more]