Ontology highlight
ABSTRACT:
SUBMITTER: Cohen ES
PROVIDER: S-EPMC4579851 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nature communications 20150914
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. Both reduced (active) ...[more]