Dataset Information

Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naive Subjects, Unaffected First-Degree Relatives and Healthy Controls From an Indigenous Population.

ABSTRACT:

Background

Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied.

Aims

To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls.

Method

Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound.

Results

Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls.

Conclusions

PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.

SUBMITTER: Molina JL

PROVIDER: S-EPMC5049519 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls From an Indigenous Population.

Molina Juan L JL González Alemán Gabriela G Florenzano Néstor N Padilla Eduardo E Calvó María M Guerrero Gonzalo G Kamis Danielle D Stratton Lee L Toranzo Juan J Molina Rangeon Beatriz B Hernández Cuervo Helena H Bourdieu Mercedes M Sedó Manuel M Strejilevich Sergio S Cloninger Claude Robert CR Escobar Javier I JI de Erausquin Gabriel A GA

Schizophrenia bulletin 20160318 6

<h4>Background</h4>Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied.<h4>Aims</h4>To test the efficacy of midbrain hyp ...[more]

PMID: 26994395

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