Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naive Subjects, Unaffected First-Degree Relatives and Healthy Controls From an Indigenous Population.

ABSTRACT:

Background

Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied.

Aims

To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls.

Method

Seventy-six subjects with chronic schizophrenia

SUBMITTER: Molina JL 

PROVIDER: S-EPMC5049519 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature