Aberrant perfusion and its connectivity within default mode network of first-episode drug-naive schizophrenia patients and their unaffected first-degree relatives.

ABSTRACT: Neural substrates behind schizophrenia (SZ) and its heritability mediated by brain function are largely unknown. Cerebral blood flow (CBF), as a biomarker of activation in the brain, reflects the neuronal metabolism, and is promisingly used to detect cerebral alteration thereby shedding light on the features of individuals at high genetic risk. We performed a cross-sectional functional magnetic resonance imaging (MRI) study enrolling 45 first-episode drug-naïve patients with SZ, 32 unaffected first-degree relatives of these patients, and 51 healthy controls (HCs). We examined CBF, CBF connectivity, and CBF topological properties. SZ patients showed increased CBF in the left medial superior frontal gyrus and right precuneus compared with HCs, and decreased CBF in the left middle temporal gy

SUBMITTER: Cui LB 

PROVIDER: S-EPMC5700958 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature