The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer.

ABSTRACT:

Background

There are several indications that the composition of the tumor stroma can contribute to the malignancy of a tumor. Here we utilized expression data sets to identify metagenes that may serve as surrogate marker for the extent of matrix production and vascularization of a tumor and to characterize prognostic molecular components of the stroma.

Methods

TCGA data sets from six cancer forms, two breast cancer microarray sets and one mRNA data set of xenografted tumors were downloaded. Using the mean correlation as distance measure compact clusters with genes representing extracellular matrix production (ECM metagene) and vascularization (endothelial metagene) were defined. Explorative Cox modeling was used to identify prognostic stromal gene sets.

Results

Clust

SUBMITTER: Winslow S 

PROVIDER: S-EPMC5095990 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature