CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

ABSTRACT:

Purpose

This study is part of a larger effort aiming to expand the knowledge of brain-enriched proteins in human cerebrospinal fluid (CSF) and to provide novel insight into the relation between such proteins and different neurodegenerative diseases.

Experimental design

Here 280 brain-enriched proteins in CSF from patients with Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are profiled. In total, 441 human samples of ventricular CSF collected post mortem and lumbar CSF collected ante mortem are analyzed using 376 antibodies in a suspension bead array setup, utilizing a direct labelling approach.

Results

Among several proteins displaying differentiated profiles between sample groups, we focus here on two synaptic proteins, neurom

SUBMITTER: Remnestal J 

PROVIDER: S-EPMC5157753 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature