Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.

ABSTRACT:

Objective

Decreased amyloid beta (Aβ) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.

Methods

We utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.

Results

Six proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated pho

SUBMITTER: Bergstrom S 

PROVIDER: S-EPMC8283172 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature