Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

ABSTRACT: Dendritic cells (DCs) play an important role in controlling T cell-mediated adaptive immunity in atherogenesis. However, the role of the basic leucine zipper transcription factor, ATF-like 3 (Batf3)-dependent CD8α⁺ DC subset in atherogenesis remains unclear. Here we show that Batf3^-/-Apoe^-/- mice, lacking CD8α⁺ DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe^-/- controls. Then, we found that CD8α⁺ DCs preferentially induce Th1 cells via secreting interleukin-12 (IL-12), and that the expression of interferon-gamma (IFN-γ)or chemokine (C-C motif) ligand 5 (CCL5) in aorta were significantly decreased in Batf3^-/-Apoe^-/- mice. We further demonstrated that ma

SUBMITTER: Li Y 

PROVIDER: S-EPMC5405198 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature