CD56^bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections.

ABSTRACT: Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of differentiation (CD)127] is expressed on NK cells, with greatest abundance on the CD56^brightCD16^dim/- (CD56^bright) subset. Here, we measured CD127 expression on CD56^bright, CD56^dimCD16⁺ (CD56^dim), or CD56^negCD16⁺ (CD56^neg) NK cell subsets of 25 uninfected donors (UD); 34 chronic HCV-infected, treatment-naïve; 25 HIV-infected, virally suppressed on antiretroviral therapy

SUBMITTER: Judge CJ 

PROVIDER: S-EPMC5470838 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature