The RNA Modification N⁶-methyladenosine and Its Implications in Human Disease.

ABSTRACT: Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control gene expression are often the target of cellular parasites, such as viruses. Gene expression is controlled through multiple mechanisms that are coordinated to ensure the proper and timely expression of each gene. Many of these mechanisms target the life cycle of the RNA molecule, from transcription to translation. Recently, another layer of regulation at the RNA level involving RNA modifications has gained renewed interest of the scientific community. The discovery that N⁶-methyladenosine (m⁶A), a modification present in mRNAs and long noncoding RNAs, can be removed by the activity of RNA demethylases, launched the

SUBMITTER: Batista PJ 

PROVIDER: S-EPMC5487527 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature