Dataset Information

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.

ABSTRACT:

Background

Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.

Methods

Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.

Results

We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.

Conclusion

Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.

SUBMITTER: Anwarullah

PROVIDER: S-EPMC5493842 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.

Anwarullah Aslam Muhammad M Badshah Mazhar M Abbasi Rashda R Sultan Aneesa A Khan Kafaitullah K Ahmad Nafees N von Engelhardt Jakob J

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 20170701

<h4>Background</h4>Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the <i>CYP2D6</i> gene (<i>CYP2D6*4</i> allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. <i>CYP2D6</i> codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently ...[more]

PMID: 28680508

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Dataset Information

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.

Background

Methods

Results

Conclusion

Publications

Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.

Similar Datasets

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