COMT Val¹⁵⁸Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

ABSTRACT: Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence development of post-traumatic stress disorder (PTSD), but its role in TBI remains unclear. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val¹⁵⁸Met polymorphism is associated with PTSD and global functional outcome as measured by the PTSD Checklist - Civilian Version and Glasgow Outcome Scale Extended (GOSE), respectively. Results in 93 predominately Caucasian subjects with mTBI show that t

SUBMITTER: Winkler EA 

PROVIDER: S-EPMC5588892 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature