Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density.

ABSTRACT: Genetic and environmental determinants of skeletal phenotypes such as bone mineral density (BMD) may converge through the epigenome, providing a tool to better understand osteoporosis pathophysiology. Because the epigenetics of BMD have been largely unexplored in humans, we performed an epigenome-wide association study (EWAS) of BMD. We undertook a large-scale BMD EWAS using the Infinium HumanMethylation450 array to measure site-specific DNA methylation in up to 5515 European-descent individuals (N_Discovery = 4614, N_Validation = 901). We associated methylation at multiple cytosine-phosphate-guanine (CpG) sites with dual-energy X-ray absorptiometry (DXA)-derived femoral neck and lumbar spine BMD. We performed sex-combined and stratified analyses, controlling for age,

SUBMITTER: Morris JA 

PROVIDER: S-EPMC5615229 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature