Prospective investigation of risk factors for prostate cancer in the UK Biobank cohort study.

ABSTRACT:

Background

Prostate cancer is the most common cancer in British men but its aetiology is not well understood. We aimed to identify risk factors for prostate cancer in British males.

Methods

We studied 219 335 men from the UK Biobank study who were free from cancer at baseline. Exposure data were collected at recruitment. Prostate cancer risk by the different exposures was estimated using multivariable-adjusted Cox proportional hazards models.

Results

In all, 4575 incident cases of prostate cancer occurred during 5.6 years of follow-up. Prostate cancer risk was positively associated with the following: black ethnicity (hazard ratio black vs white=2.61, 95% confidence interval=2.10-3.24); having ever had a prostate-specific antigen test (1.31, 1.23-1.40); being diagnose

SUBMITTER: Perez-Cornago A 

PROVIDER: S-EPMC5680461 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature