Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study.

ABSTRACT:

Objective

To clarify the temporal relationship between systemic inflammation and neurodegeneration, we examined whether a higher level of circulating inflammatory markers during midlife was associated with smaller brain volumes in late life using a large biracial prospective cohort study.

Methods

Plasma levels of systemic inflammatory markers (fibrinogen, albumin, white blood cell count, von Willebrand factor, and Factor VIII) were assessed at baseline in 1,633 participants (mean age 53 [5] years, 60% female, 27% African American) enrolled in the Atherosclerosis Risk in Communities Study. Using all 5 inflammatory markers, an inflammation composite score was created for each participant. We assessed episodic memory and regional brain volumes, using 3T MRI, 24 years later.

SUBMITTER: Walker KA 

PROVIDER: S-EPMC5705246 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature