Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

ABSTRACT: The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show that macrophage metabolites are defined in a specific tissue context, and these metabolites are crucially linked to tissue-resident macrophage functions. We find the peritoneum to be rich in glutamate, a glutaminolysis-fuel that is exploited by peritoneal-resident macrophages to maintain respiratory burst during phagocytosis via enhancing mitochondrial complex-II metabolism. This niche-supported, inducible mitochondrial function is dependent on protein kinase C activity, and is required to fine-tune the cytokine responses that control inflammation. In addition, we find that peritoneal-resident macrophage mitochondria are recruited to p

SUBMITTER: Davies LC 

PROVIDER: S-EPMC5727035 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature