House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.

ABSTRACT:

Background

The peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood.

Objectives

We investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects.

Methods

The endotoxin–leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005–2006 (n=6,254) and the Agricultural Lung Health Study (ALHS; n=1,708). In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin receptor]-by-environment interaction in the endotoxin–leukocyte

SUBMITTER: Fessler MB 

PROVIDER: S-EPMC5730525 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature