"Albumin Hitchhiking" with an Evans Blue Analog for Cancer Theranostics.
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ABSTRACT:
SUBMITTER: Ehlerding EB
PROVIDER: S-EPMC5771095 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
"Albumin Hitchhiking" with an Evans Blue Analog for Cancer Theranostics.
Ehlerding Emily B EB Lan Xiaoli X Cai Weibo W
Theranostics 20180101 3
Although <sup>177</sup>Lu-DOTA-TATE was recently approved in Europe for the treatment of certain neuroendocrine tumors, continued development and optimization has been ongoing to further improve the therapeutic efficacy of somatostatin receptor 2 targeted peptide receptor radionuclide therapy, as well as reducing the renal toxicity. In this work, the use of an Evans blue analog for "albumin hitchhiking" resulted in significant improvement in both the imaging performance and therapeutic efficacy ...[more]
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