DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

ABSTRACT: Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry. Of 31 discovery-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferroni correction (discovery: N = 9,828, p < 1.0 × 10^-7; replication: N = 7,182, p <

SUBMITTER: Richard MA 

PROVIDER: S-EPMC5812919 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature