Ontology highlight
ABSTRACT:
SUBMITTER: Behera V
PROVIDER: S-EPMC5823854 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180222 1
Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid cell lines. The impact of discriminatory single-nucleotide variants on TF ChIP signal enables definition at single base resolution of in vivo binding characteristics of nuclear facto ...[more]