Longitudinal intra-individual variability in neuropsychological performance relates to white matter changes in HIV.

ABSTRACT:

Objectives

Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals.

Method

The sample consisted of 38 HIV+ participants and 26 HIV- control participants who underwent neuroimaging and a neuropsychological evaluation at baseline and at 2-year follow-up evaluation.

Results

Among HIV+ participants, increases in IIV (greater dispersion) were related to lower fractional anisotropy (FA) values in t

SUBMITTER: Jones JD 

PROVIDER: S-EPMC5845766 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature