Identification of Anti-Trypanosoma cruzi Lead Compounds with Putative Immunomodulatory Activity.

ABSTRACT: In seeking substitutions for the current Chagas disease treatment, which has several relevant side effects, new therapeutic candidates have been extensively investigated. In this context, a balanced interaction between mediators of the host immune response seems to be a key element for therapeutic success, as a proinflammatory microenvironment modulated by interleukin-10 (IL-10) is shown to be relevant to potentiate anti-Trypanosoma cruzi drug activity. This study aimed to identify the potential immunomodulatory activities of the anti-T. cruzi K777, pyronaridine (PYR), and furazolidone (FUR) compounds in peripheral blood mononuclear cells (PBMC) from noninfected (NI) subjects and chronic Chagas disease (CD) patients. Our results showed low cytotoxicity to PBMC populations, wi

SUBMITTER: Otta DA 

PROVIDER: S-EPMC5913944 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature