Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank.

ABSTRACT:

Objective

To determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.

Design

Mendelian randomisation study.

Setting

UK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.

Participants

European descent participants from the UK Biobank cohort (n=372 791) and the TAG consortium (n=74 035).

Main outcome measures

Risk of current and past smoking, number of cigarettes smoked per day, age of smoking initiation.

Results

The Mendelian randomisation analysis indicated that each standard deviation increment in body mass index (4.6) increased the risk of being a smoker (odds ratio 1.18 (95% confidence interval 1.13 to 1.23), P<0.001). This association was replicate

SUBMITTER: Carreras-Torres R 

PROVIDER: S-EPMC5953237 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature