Transient immediate postoperative homotopic functional disconnectivity in low-grade glioma patients.

ABSTRACT:

Background and purpose

The aim of this longitudinal study is to evaluate large-scale perioperative resting state networks reorganization in patients with diffuse low-grade gliomas following awake surgery.

Materials and methods

Eighty-two patients with diffuse low-grade gliomas were prospectively enrolled and underwent awake surgical resection. Resting-state functional images were acquired at three time points: preoperative (MRI-1), immediate postoperative (MRI-2) and three months after surgery (MRI-3). We simultaneously performed perfusion-weighted imaging.

Results

Comparing functional connectivity between MRI-1 and MRI-2, we observed a statistically significant functional homotopy decrease in cortical and subcortical supratentorial structures (P < 0.05). A functional

SUBMITTER: Coget A 

PROVIDER: S-EPMC5987867 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature