Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.

ABSTRACT:

Background

Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood.

Methods

We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years.

Results

Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years.

SUBMITTER: Vuong AM 

PROVIDER: S-EPMC5997562 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature