The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.

ABSTRACT:

Context

Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce.

Objective

To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia.

Design

Individual participant data meta-analysis.

Setting

Sixteen cohorts participating in the Thyroid Studies Collaboration (n = 42,162).

Main outcome measures

Primary outcome measure was anemia (hemoglobin <130 g/L in men and <120 g/L in women).

Results

Cross-sectionally, participants with abnormal thyroid status had an increased risk of having anemia compared with euthyroid participants [overt hypothyroidism, pooled OR 1.84 (95% CI 1.35 to 2.50), subclinical hypothyroidism

SUBMITTER: Wopereis DM 

PROVIDER: S-EPMC6179176 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature