Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis.

ABSTRACT:

Importance

In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal and treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings.

Objective

To assess cross-sectional and longitudinal associations of baseline thyroid dysfunction with cognitive function and dementia.

Design, setting, and participants

This multicohort individual participant data analysis assessed 114 267 person-years (median, 1.7-11.3 years) of follow-up for cognitive function and 525 222 person-years (median, 3.8-15.3 years) for dementia between 1989 and 2017. Analyses on cognitive function included 21 cohorts comprising 38 144 participants. Analyses on dementia included eight cohorts with a total of 20

SUBMITTER: van Vliet NA 

PROVIDER: S-EPMC8424529 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature