Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts.

ABSTRACT:

Context

Hyperthyroidism is associated with increased fracture risk, but it is not clear if lower thyroid-stimulating hormone (TSH) and higher free thyroxine (FT4) in euthyroid individuals are associated with fracture risk.

Objective

To evaluate the association of TSH and FT4 with incident fractures in euthyroid individuals.

Design

Individual participant data analysis.

Setting

Thirteen prospective cohort studies with baseline examinations between 1981 and 2002.

Participants

Adults with baseline TSH 0.45 to 4.49 mIU/L.

Main outcome measures

Primary outcome was incident hip fracture. Secondary outcomes were any, nonvertebral, and vertebral fractures. Results were presented as hazard ratios (HRs) with 95% confidence interval (CI) adjusted for age and

SUBMITTER: Aubert CE 

PROVIDER: S-EPMC6283437 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature