Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer.

ABSTRACT:

Background

Even though the post-operative outcome varies greatly among patients with nodal positive colon cancer (UICC stage III), personalized prediction of systemic disease recurrence is currently insufficient. We investigated in a retrospective setting whether genetic and immunological biomarkers can be applied for stratification of distant metastasis occurrence risk.

Methods

Eighty four patients with complete resection (R0) of stage III colon cancer from two clinical centres were analysed for genetic biomarkers: microsatellite instability, oncogenic mutations in KRAS exon2 and BRAF exon15, expression of osteopontin and the metastasis-associated genes SASH1 and MACC1. Tumor-infiltrating CD3 and CD8 positive T-cells were quantified by immunocytochemistry. Results were corr

SUBMITTER: Sperlich A 

PROVIDER: S-EPMC6194664 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature