Cox15 interacts with the cytochrome bc₁ dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase.

ABSTRACT: The heme a molecule is an obligatory cofactor in the terminal enzyme complex of the electron transport chain, cytochrome c oxidase. Heme a is synthesized from heme o by a multi-spanning inner membrane protein, heme a synthase (Cox15 in the yeast Saccharomyces cerevisiae). The insertion of heme a is critical for cytochrome c oxidase function and assembly, but this process has not been fully elucidated. To improve our understanding of heme a insertion into cytochrome c oxidase, here we investigated the protein-protein interactions that involve Cox15 in S. cerevisiae In addition to observing Cox15 in homooligomeric complexes, we found that a portion of Cox15 also associates with the mitochondrial respiratory supercom

SUBMITTER: Herwaldt EJ 

PROVIDER: S-EPMC6200925 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature