Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease.
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ABSTRACT:
SUBMITTER: Suyama K
PROVIDER: S-EPMC6201370 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease.
Suyama Kaori K Sakai Daisuke D Hirayama Noriaki N Nakamura Yoshihiko Y Matsushita Erika E Terayama Hayato H Qu Ning N Tanaka Osamu O Sakabe Kou K Watanabe Masahiko M
Journal of cellular and molecular medicine 20180911 11
Intervertebral discs (IVD) degeneration, which is caused by ageing or mechanical stress, leads to IVD disease, including back pain and sciatica. The cytokine interleukin (IL)-17A is elevated in NP cells during IVD disease. Here we explored the pharmacotherapeutic potential of IL-17A for the treatment of IVD disease using small-molecule inhibitors that block binding of IL-17A to the IL-17A receptor (IL-17RA). Treatment of NP cells with IL-17A increased expression of cyclooxygenase-2 (COX-2), IL-6 ...[more]
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